Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

Senataxin, mutated in the human genetic disorder ataxia with oculomotor apraxia type 2 (AOA2), plays an important role in maintaining genome integrity by coordination of transcription, DNA replication, and the DNA damage response. We demonstrate that senataxin is essential for spermatogenesis and th...

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Hauptverfasser: Becherel, Olivier J., Yeo, Abrey J., Stellati, Alissa, Heng, Evelyn Y. H., Luff, John, Suraweera, Amila M., Woods, Rick, Fleming, Jean, Carrie, Dianne, McKinney, Kristine, Xu, Xiaoling, Deng, Chuxia, Lavin, Martin F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623790/
https://ncbi.nlm.nih.gov/pubmed/23593030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003435
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