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N152G, -S, and -T Substitutions in CMY-2 β-Lactamase Increase Catalytic Efficiency for Cefoxitin and Inactivation Rates for Tazobactam

Class C cephalosporinases are a growing threat, and clinical inhibitors of these enzymes are currently unavailable. Previous studies have explored the role of Asn152 in the Escherichia coli AmpC and P99 enzymes and have suggested that interactions between C-6′ or C-7′ substituents on penicillins or...

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Detalhes bibliográficos
Main Authors: Skalweit, Marion J., Li, Mei, Conklin, Benjamin C., Taracila, Magdalena A., Hutton, Rebecca A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623365/
https://ncbi.nlm.nih.gov/pubmed/23318801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01334-12
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