Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO(3)(−) secretion by reciprocal regulation of apical and basolateral membrane Cl(−)-HCO(3)(−) exchangers

BACKGROUND AND PURPOSE: Our recent studies on human airway serous-like Calu-3 cells showed that cAMP agonists stimulated a HCO(3)(−) rich secretion containing up to 80 mM HCO(3)(−). This alkaline secretion relied on a coordinated switch in the activity of distinct Cl(−)-HCO(3)(−) anion exchangers (A...

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Bibliografiske detaljer
Main Authors: Garnett, James P, Hickman, Emma, Tunkamnerdthai, Orathai, Cuthbert, Alan W, Gray, Michael A
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623064/
https://ncbi.nlm.nih.gov/pubmed/23215877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12085
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