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Humanized Rag2(−/−) γc(−/−) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year
HIV-1 infection is characterized by life-long viral persistence and continued decline of helper CD4 T cells. The new generation of humanized mouse models that encompass RAG-hu, hNOG and BLT mice have been shown to be susceptible to HIV-1 infection and display CD4 T cell loss. Productive infection ha...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3622870/ https://ncbi.nlm.nih.gov/pubmed/19922970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.10.034 |
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