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Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy

Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In...

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Hlavní autoři: Pramanik, Rocky, Sheng, Xia, Ichihara, Brian, Heisterkamp, Nora, Mittelman, Steven D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622767/
https://ncbi.nlm.nih.gov/pubmed/23332453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2012.12.013
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