Mesenchymal Stem Cells Expressing Insulin-like Growth Factor-I (MSC(IGF)) Promote Fracture Healing and Restore New Bone Formation in Irs1 Knock-out Mice: Analyses of MSC(IGF) Autocrine and Paracrine Regenerative Effects

Failures of fracture repair (non-unions) occur in 10% of all fractures. The use of mesenchymal stem cells (MSC) in tissue regeneration appears to be rationale, safe and feasible. The contributions of MSC to the reparative process can occur through autocrine as well as paracrine effects. The primary...

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Main Authors: Granero-Moltó, Froilán, Myers, Timothy J., Weis, Jared A., Longobardi, Lara, Li, Tieshi, Yan, Yun, Case, Natasha, Rubin, Janet, Spagnoli, Anna
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622704/
https://ncbi.nlm.nih.gov/pubmed/21786367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.697
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