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Redox-Activated Manganese-Based MR Contrast Agent

Here we report a simple Mn coordination complex with utility as a redox-sensitive MR probe. The HBET ligand stabilizes both the Mn(2+) and Mn(3+) oxidation states. In the presence of glutathione (GSH), low relaxivity Mn(III)-HBET is converted to high relaxivity Mn(II)-HBET with a 3-fold increase in...

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Autors principals: Loving, Galen S., Mukherjee, Shreya, Caravan, Peter
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622546/
https://ncbi.nlm.nih.gov/pubmed/23510406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja312610j
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