Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

The catechol-O-methyltransferase (COMT) enzyme is critical for the catabolic regulation of synaptic dopamine, resulting in altered cortical functioning. The COMT Val(158)Met polymorphism has been implicated in human mental illness, with Met/Met homozygotes associated with increased susceptibility to...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Norrholm, Seth Davin, Jovanovic, Tanja, Smith, Alicia K., Binder, Elisabeth, Klengel, Torsten, Conneely, Karen, Mercer, Kristina B., Davis, Jennifer S., Kerley, Kimberly, Winkler, Jennifer, Gillespie, Charles F., Bradley, Bekh, Ressler, Kerry J.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2013
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622057/
https://ncbi.nlm.nih.gov/pubmed/23596403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2013.00030
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares