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Identification of regions of rabbit muscle pyruvate kinase important for allosteric regulation by phenylalanine, detected by H/D exchange mass spectrometry

Mass spectrometry has been used to determine the number of exchangeable backbone amide protons and the associated rate constants that are altered when rabbit muscle pyruvate kinase (rM(1)-PYK) binds either the allosteric inhibitor (phenylalanine) or a non-allosteric analogue of the inhibitor. Alanin...

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Bibliografiska uppgifter
Huvudupphovsmän: Prasannan, Charulata B., Villar, Maria T., Artigues, Antonio, Fenton, Aron W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621738/
https://ncbi.nlm.nih.gov/pubmed/23418858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400117q
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