Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as SREBP-2, in the brains of diabetic mice, leading to a reduction of cholesterol...

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Bibliographic Details
Main Authors: Suzuki, Ryo, Ferris, Heather A., Chee, Melissa J., Maratos-Flier, Eleftheria, Kahn, C. Ronald
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621654/
https://ncbi.nlm.nih.gov/pubmed/23585733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001532
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