DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage.

The hypothesis that DNA topoisomerase II facilitates the separation of replicated sister chromatids was tested by examining the consequences of chromosome segregation in the absence of topoisomerase II activity. We observed a substantial elevation in the rate of nondisjunction in top2/top2 cells inc...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Holm, C, Stearns, T, Botstein, D
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1989
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2538717/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.1.159-168.1989
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