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DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response

Ab’s to the α-chain of the IL-2 receptor (anti-CD25) are used clinically to achieve immunosuppression. Here we investigated the effects of DNA vaccination with the whole CD25 gene on the induction of rat adjuvant arthritis. The DNA vaccine protected the rats and led to a shift in the cytokine profil...

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Detalhes bibliográficos
Main Authors: Mimran, Avishai, Mor, Felix, Carmi, Pnina, Quintana, Francisco J., Rotter, Varda, Cohen, Irun R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC362112/
https://ncbi.nlm.nih.gov/pubmed/15067325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200417772
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