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Sirtuin Deacetylation Mechanism and Catalytic Role of the Dynamic Cofactor Binding Loop
Sirtuins constitute a novel family of protein deacetylases and play critical roles in epigenetics, cell death, and metabolism. In spite of numerous experimental studies, the key and most complicated stage of its NAD(+)-dependent catalytic mechanism remains to be elusive. Herein by employing Born-Opp...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3621114/ https://ncbi.nlm.nih.gov/pubmed/23585919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jz302015s |
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