Novel Dedifferentiated Liposarcoma Xenograft Models Reveal PTEN Down-Regulation as a Malignant Signature and Response to PI3K Pathway Inhibition

Liposarcoma is a type of soft tissue sarcoma that exhibits poor survival and a high recurrence rate. Treatment is generally limited to surgery and radiation, which emphasizes the need for better understanding of this disease. Because very few in vivo and in vitro models can reproducibly recapitulate...

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Detalhes bibliográficos
Main Authors: Smith, Kathleen B., Tran, Linh M., Tam, Brenna M., Shurell, Elizabeth M., Li, Yunfeng, Braas, Daniel, Tap, William D., Christofk, Heather R., Dry, Sarah M., Eilber, Fritz C., Wu, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620414/
https://ncbi.nlm.nih.gov/pubmed/23416162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.01.002
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