Expression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein

Hepatitis C virus (HCV) contributes substantially to human morbidity and mortality world-wide. The development of HCV genomes expressing heterologous proteins has enhanced the ability to study viral infection, but existing systems have drawbacks. Recombinant viruses often require adaptive mutations...

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Main Authors: Horwitz, Joshua A., Dorner, Marcus, Friling, Tamar, Donovan, Bridget M., Vogt, Alexander, Loureiro, Joana, Oh, Thomas, Rice, Charles M., Ploss, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620014/
https://ncbi.nlm.nih.gov/pubmed/23485372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.01.019
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