Impaired dimer assembly and decreased stability of naturally recurring R260C mutant A subunit for coagulation factor XIII

Factor XIII (FXIII) consists of catalytic A subunits (FXIII-A) and carrier B subunits. Congenital FXIII deficiency is a severe bleeding disorder. We previously identified an R260C missense mutation and an exon-IV deletion in Japanese patients’ F13A genes. To characterize the molecular basis of this...

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Bibliografiske detaljer
Main Authors: Maeda, Shoko, Zhang, Wei Guang, Souri, Masayoshi, Yee, Vivien C., Ichinose, Akitada
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Regular Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619964/
https://ncbi.nlm.nih.gov/pubmed/22923741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvs088
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