Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase

Homology-directed repair (HDR) is a critical pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. Efficient HDR is thought to be crucial for maintenance of genomic integrity during organismal development and tumor suppression. However, most mammalian HDR studies have focused...

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Detaylı Bibliyografya
Asıl Yazarlar: Kass, Elizabeth M., Helgadottir, Hildur R., Chen, Chun-Chin, Barbera, Maria, Wang, Raymond, Westermark, Ulrica K., Ludwig, Thomas, Moynahan, Mary Ellen, Jasin, Maria
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619303/
https://ncbi.nlm.nih.gov/pubmed/23509290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216824110
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