BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study

BACKGROUND: Breast cancer 1, early onset (BRCA1) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in...

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Detalhes bibliográficos
Main Authors: Lesnock, J L, Darcy, K M, Tian, C, DeLoia, J A, Thrall, M M, Zahn, C, Armstrong, D K, Birrer, M J, Krivak, T C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619264/
https://ncbi.nlm.nih.gov/pubmed/23462720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.70
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