Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of anti-angiogenic therapy resistance

PURPOSE: To identify mediators of glioblastoma anti-angiogenic therapy resistance and target these mediators in xenografts. EXPERIMENTAL DESIGN: We performed microarray analysis comparing bevacizumab-resistant glioblastomas (BRGs) to pre-treatment tumors from the same patients. We established novel...

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Detalhes bibliográficos
Main Authors: Jahangiri, Arman, DeLay, Michael, Miller, Liane M., Carbonell, W. Shawn, Hu, Yu-Long, Lu, Kan, Tom, Maxwell W., Paquette, Jesse, Tokuyasu, Taku A., Tsao, Sean, Marshall, Roxanne, Perry, Arie, Bjorgan, Kirsten M., Chaumeil, Myriam M., Ronen, Sabrina M., Bergers, Gabriele, Aghi, Manish K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618605/
https://ncbi.nlm.nih.gov/pubmed/23307858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1281
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