Enhanced Human Tissue Microdialysis Using Hydroxypropyl-ß-Cyclodextrin as Molecular Carrier

Microdialysis sampling of lipophilic molecules in human tissues is challenging because protein binding and adhesion to the membrane limit recovery. Hydroxypropyl-ß-cyclodextrin (HP-ß-CD) forms complexes with hydrophobic molecules thereby improving microdialysis recovery of lipophilic molecules in vi...

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Main Authors: May, Marcus, Batkai, Sandor, Zoerner, Alexander A., Tsikas, Dimitrios, Jordan, Jens, Engeli, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618094/
https://ncbi.nlm.nih.gov/pubmed/23577137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060628
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