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Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

Three isoforms of phosphatidylinositol-4-phosphate 5-kinase (PIP5KIα, PIP5KIβ, and PIP5KIγ) can each catalyze the final step in the synthesis of phosphatidylinositol-4,5-bisphosphate (PIP(2)), which in turn can be either converted to second messengers or bind directly to and thereby regulate protein...

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Bibliografiske detaljer
Main Authors: Wang, Yanfeng, Zhao, Liang, Suzuki, Aae, Lian, Lurong, Min, Sang H., Wang, Ziqian, Litvinov, Rustem I., Stalker, Timothy J., Yago, Tadayuki, Klopocki, Arkadiusz G., Schmidtke, David W., Yin, Helen, Choi, John K., McEver, Rodger P., Weisel, John W., Hartwig, John H., Abrams, Charles S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617636/
https://ncbi.nlm.nih.gov/pubmed/23372168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-445205
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