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Chronic lymphocytic leukemia cells induce defective LFA-1–directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide
T lymphocytes have an essential role in adaptive immunity and rely on the activation of integrin lymphocyte function–associated antigen-1 (LFA-1) to mediate cell arrest and migration. In cancer, malignant cells modify the immune microenvironment to block effective host antitumor responses. We show f...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617635/ https://ncbi.nlm.nih.gov/pubmed/23325833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-448332 |
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