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Chronic lymphocytic leukemia cells induce defective LFA-1–directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

T lymphocytes have an essential role in adaptive immunity and rely on the activation of integrin lymphocyte function–associated antigen-1 (LFA-1) to mediate cell arrest and migration. In cancer, malignant cells modify the immune microenvironment to block effective host antitumor responses. We show f...

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Autori principali: Ramsay, Alan G., Evans, Rachel, Kiaii, Shahryar, Svensson, Lena, Hogg, Nancy, Gribben, John G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617635/
https://ncbi.nlm.nih.gov/pubmed/23325833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-448332
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