Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the Huntingtin (HTT) gene. Recently, induced pluripotent stem cell (iPSC) lines carrying atypical and aggressive (CAG60+) HD variants have been generated and exhibit disparate mole...

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Detalhes bibliográficos
Main Authors: Niclis, Jonathan C., Pinar, Anita, Haynes, John M., Alsanie, Walaa, Jenny, Robert, Dottori, Mirella, Cram, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617399/
https://ncbi.nlm.nih.gov/pubmed/23576953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00037
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