Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity

Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks and numerous transcriptional regulators. We combined experimental approaches and computational modeling to investigate the mechanisms controll...

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Hauptverfasser: Carbo, Adria, Hontecillas, Raquel, Kronsteiner, Barbara, Viladomiu, Monica, Pedragosa, Mireia, Lu, Pinyi, Philipson, Casandra W., Hoops, Stefan, Marathe, Madhav, Eubank, Stephen, Bisset, Keith, Wendelsdorf, Katherine, Jarrah, Abdul, Mei, Yongguo, Bassaganya-Riera, Josep
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617204/
https://ncbi.nlm.nih.gov/pubmed/23592971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003027
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