Fulvestrant-Induced Cell Death and Proteasomal Degradation of Estrogen Receptor α Protein in MCF-7 Cells Require the CSK c-Src Tyrosine Kinase

Fulvestrant is a representative pure antiestrogen and a Selective Estrogen Receptor Down-regulator (SERD). In contrast to the Selective Estrogen Receptor Modulators (SERMs) such as 4-hydroxytamoxifen that bind to estrogen receptor α (ERα) as antagonists or partial agonists, fulvestrant causes protea...

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Hlavní autoři: Yeh, Wei-Lan, Shioda, Keiko, Coser, Kathryn R., Rivizzigno, Danielle, McSweeney, Kristen R., Shioda, Toshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617152/
https://ncbi.nlm.nih.gov/pubmed/23593342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060889
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