Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.

We have studied the effect of plasminogen activator inhibitors PAI-1 and PAI-2 on the binding of urokinase-type plasminogen activator (u-PA) to its receptor in the human choriocarcinoma cell line JAR. With 125I-labeled ligands in whole-cell binding assays, both uncomplexed u-PA and u-PA-inhibitor co...

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Detalhes bibliográficos

Publicado no:	Cell Regul
Principais autores:	Jensen, P H, Christensen, E I, Ebbesen, P, Gliemann, J, Andreasen, P A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Cell Biology 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361701/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1966892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.1.13.1043
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