Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action

BACKGROUND: The discovery and development of anti-malarial compounds of plant origin and semisynthetic derivatives thereof, such as quinine (QN) and chloroquine (CQ), has highlighted the importance of these compounds in the treatment of malaria. Ursolic acid analogues bearing an acetyl group at C-3...

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Bibliografiske detaljer
Main Authors: da Silva, Gloria NS, Maria, Nicole RG, Schuck, Desirée C, Cruz, Laura N, de Moraes, Miriam S, Nakabashi, Myna, Graebin, Cedric, Gosmann, Grace, Garcia, Célia RS, Gnoatto, Simone CB
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616855/
https://ncbi.nlm.nih.gov/pubmed/23497003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-89
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