16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus

BACKGROUND: The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naïve mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as well as kidney and brain involvement. We assessed behavior and brain pathology of...

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Detalhes bibliográficos
Main Authors: Kivity, Shaye, Katzav, Aviva, Arango, Maria Teresa, Landau-Rabi, Moran, Zafrir, Yaron, Agmon-Levin, Nancy, Blank, Miri, Anaya, Juan-Manuel, Mozes, Edna, Chapman, Joab, Shoenfeld, Yehuda
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616817/
https://ncbi.nlm.nih.gov/pubmed/23556432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-11-90
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