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Molecular Analysis of a Case of Thanatophoric Dysplasia Reveals Two de novo FGFR3 Missense Mutations located in cis

OBJECTIVES: Thanatophoric dysplasia (TD) is the most common form of lethal skeletal dysplasia. It is primarily an autosomal dominant disorder and is characterised by macrocephaly, a narrow thorax, short ribs, brachydactyly, and hypotonia. In addition to these core phenotypic features, TD type I invo...

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Detalhes bibliográficos
Main Authors: Marquis-Nicholson, Renate, Aftimos, Salim, Love, Donald R.
Formato: Artigo
Idioma:Inglês
Publicado em: Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616804/
https://ncbi.nlm.nih.gov/pubmed/23573386
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