Busulfan Conditioning Enhances Engraftment of Hematopoietic Donor-derived Cells in the Brain Compared With Irradiation

Hematopoietic stem cell gene therapy for neurological disorders relies on transmigration of donor-derived monocytes to the brain, where they can engraft as microglia and deliver therapeutic proteins. Many mouse studies use whole-body irradiation to investigate brain transmigration pathways, but chem...

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Detalhes bibliográficos
Main Authors: Wilkinson, Fiona L, Sergijenko, Ana, Langford-Smith, Kia J, Malinowska, Marcela, Wynn, Rob F, Bigger, Brian W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616529/
https://ncbi.nlm.nih.gov/pubmed/23423338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.29
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