MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia

RATIONALE: Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently inv...

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Autors principals: Spinetti, Gaia, Fortunato, Orazio, Caporali, Andrea, Shantikumar, Saran, Marchetti, Micol, Meloni, Marco, Descamps, Betty, Floris, Ilaria, Sangalli, Elena, Vono, Rosa, Faglia, Ezio, Specchia, Claudia, Pintus, Gianfranco, Madeddu, Paolo, Emanueli, Costanza
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616367/
https://ncbi.nlm.nih.gov/pubmed/23233752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300418
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