Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation of cell cycle, mitosis, DNA repair and proliferat...

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Detalhes bibliográficos
Main Authors: Dementyeva, Elena, Kryukov, Fedor, Kubiczkova, Lenka, Nemec, Pavel, Sevcikova, Sabina, Ihnatova, Ivana, Jarkovsky, Jiri, Minarik, Jiri, Stefanikova, Zdena, Kuglik, Petr, Hajek, Roman
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615957/
https://ncbi.nlm.nih.gov/pubmed/23522059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-77
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