Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells

We reported that the class I HDAC inhibitor entinostat induced apoptosis in erbB2-overexpressing breast cancer cells via downregulation of erbB2 and erbB3. Here, we study the molecular mechanism by which entinostat dual-targets erbB2/erbB3. Treatment with entinostat had no effect on erbB2/erbB3 mRNA...

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Bibliografiske detaljer
Main Authors: Wang, S, Huang, J, Lyu, H, Lee, C-K, Tan, J, Wang, J, Liu, B
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615747/
https://ncbi.nlm.nih.gov/pubmed/23519125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.79
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