Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease

The presence of α-synuclein aggregates in the characteristic Lewy body pathology seen in idiopathic Parkinson's disease (PD), together with α-synuclein gene mutations in familial PD, places α-synuclein at the center of PD pathogenesis. Decreased levels of the chaperone-mediated autophagy (CMA)...

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Autori principali: Alvarez-Erviti, L, Seow, Y, Schapira, A HV, Rodriguez-Oroz, M C, Obeso, J A, Cooper, J M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615743/
https://ncbi.nlm.nih.gov/pubmed/23492776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.73
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