Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity

Glioblastoma multiforme (GBM) is the most lethal and common malignant human brain tumor. The intrinsic resistance of highly invasive GBM cells to radiation- and chemotherapy-induced apoptosis accounts for the generally dismal treatment outcomes. This study investigated ophiobolin A (OP-A), a fungal...

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Detalhes bibliográficos
Main Authors: Bury, M, Girault, A, Mégalizzi, V, Spiegl-Kreinecker, S, Mathieu, V, Berger, W, Evidente, A, Kornienko, A, Gailly, P, Vandier, C, Kiss, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615734/
https://ncbi.nlm.nih.gov/pubmed/23538442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.85
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