Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model

Tumors develop when infiltrating immune cells contribute growth stimuli, and cancer cells are selected to survive within such a cytotoxic microenvironment. One possible immune-escape mechanism is the upregulation of PI-9 (Serpin B9) within cancer cells. This serine proteinase inhibitor selectively i...

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Detalhes bibliográficos
Main Authors: Schiffer, S, Hansen, H P, Hehmann-Titt, G, Huhn, M, Fischer, R, Barth, S, Thepen, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615217/
https://ncbi.nlm.nih.gov/pubmed/23524591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.4
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