Actin Polymerization Negatively Regulates p53 Function by Impairing Its Nuclear Import in Response to DNA Damage

Actin, one of the most evolutionarily conservative proteins in eukaryotes, is distributed both in the cytoplasm and the nucleus, and its dynamics plays important roles in numerous cellular processes. Previous evidence has shown that actin interacts with p53 and this interaction increases in the proc...

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Main Authors: Wang, Ling, Wang, Min, Wang, Shuyan, Qi, Tianyang, Guo, Lijing, Li, Jinjiao, Qi, Wenjing, Ampah, Khamal Kwesi, Ba, Xueqing, Zeng, Xianlu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615075/
https://ncbi.nlm.nih.gov/pubmed/23565200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060179
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