PARP Inhibition Sensitizes to Low Dose-Rate Radiation TMPRSS2-ERG Fusion Gene-Expressing and PTEN-Deficient Prostate Cancer Cells

Exposure to genotoxic agents, such as irradiation produces DNA damage, the toxicity of which is augmented when the DNA repair is impaired. Poly (ADP-ribose) polymerase (PARP) inhibitors were found to be “synthetic lethal” in cells deficient in BRCA1 and BRCA2 that impair homologous recombination. Ho...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Chatterjee, Payel, Choudhary, Gaurav S., Sharma, Arishya, Singh, Kamini, Heston, Warren D., Ciezki, Jay, Klein, Eric A., Almasan, Alexandru
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614551/
https://ncbi.nlm.nih.gov/pubmed/23565244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060408
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares