Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements.

Long-term regulation of mammalian steroid hormone synthesis occurs principally by transcriptional regulation of the gene for the rate-limiting cholesterol side-chain cleavage enzyme P450scc. Adrenal steroidogenesis is regulated primarily by two hormones: adrenocorticotropin, which works via cyclic A...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Moore, C C, Brentano, S T, Miller, W L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1700277/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.11.6013-6023.1990
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