Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK

Molecular mechanisms specific to colitis-associated cancers have been poorly characterized. Using comparative whole-genome expression profiling, we observed differential expression of epiregulin (EREG) in mouse models of colitis-associated, but not sporadic, colorectal cancer. Similarly, EREG expres...

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Main Authors: Neufert, Clemens, Becker, Christoph, Türeci, Özlem, Waldner, Maximilian J., Backert, Ingo, Floh, Katharina, Atreya, Imke, Leppkes, Moritz, Jefremow, Andre, Vieth, Michael, Schneider-Stock, Regine, Klinger, Patricia, Greten, Florian R., Threadgill, David W., Sahin, Ugur, Neurath, Markus F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613905/
https://ncbi.nlm.nih.gov/pubmed/23549083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63748
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