A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells

Previous studies proposed that myosin-Va regulates apoptosis by sequestering pro-apoptotic Bmf to the actin cytoskeleton through dynein light chain-2 (DLC2). Adhesion loss or other cytoskeletal perturbations would unleash Bmf, allowing it to bind and inhibit pro-survival Bcl2 proteins. Here, we demo...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Izidoro-Toledo, T C, Borges, A C, Araújo, D D, Leitão Mazzi, D P S, Nascimento, F O, Sousa, J F, Alves, C P, Paiva, A P B, Trindade, D M, Patussi, E V, Peixoto, P M, Kinnally, K W, Espreafico, E M
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613824/
https://ncbi.nlm.nih.gov/pubmed/23519116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.45
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk