Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific ChIP-seq method

Spontaneous DNA damage may occur nonrandomly in the genome, especially when genome maintenance mechanisms are undermined. We developed single-strand DNA (ssDNA)–associated protein immunoprecipitation followed by sequencing (SPI-seq) to map genomic hotspots of DNA damage. We demonstrated this method...

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Detalhes bibliográficos
Main Authors: Zhou, Zhi-Xiong, Zhang, Mei-Jun, Peng, Xu, Takayama, Yuko, Xu, Xing-Ya, Huang, Ling-Zhi, Du, Li-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613587/
https://ncbi.nlm.nih.gov/pubmed/23249883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.146357.112
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