G protein-coupled purinergic receptor GPR17 mediates orexigenic effects of FoxO1 in AgRP neurons

Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake. But druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of anorexigenic signaling by insulin or leptin in AgRP neurons fails to affect food intake. FoxO...

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Detalhes bibliográficos
Main Authors: Ren, Hongxia, Orozco, Ian J., Su, Ya, Suyama, Shigetomo, Gutiérrez-Juárez, Roger, Horvath, Tamas L., Wardlaw, Sharon L., Plum, Leona, Arancio, Ottavio, Accili, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613436/
https://ncbi.nlm.nih.gov/pubmed/22682251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.04.032
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