G protein-coupled purinergic receptor GPR17 mediates orexigenic effects of FoxO1 in AgRP neurons

Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake. But druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of anorexigenic signaling by insulin or leptin in AgRP neurons fails to affect food intake. FoxO...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ren, Hongxia, Orozco, Ian J., Su, Ya, Suyama, Shigetomo, Gutiérrez-Juárez, Roger, Horvath, Tamas L., Wardlaw, Sharon L., Plum, Leona, Arancio, Ottavio, Accili, Domenico
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2012
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613436/
https://ncbi.nlm.nih.gov/pubmed/22682251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.04.032
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