Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

Insulin receptor substrate (IRS) proteins play important roles in hepatic nutrient homeostasis. Since glucokinase (GK) and glucokinase regulatory protein (GKRP) function as key glucose sensors, we have investigated the expression of GK and GKRP in liver of Irs-2 deficient mice and Irs2(−/−) mice whe...

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Detalhes bibliográficos
Main Authors: Roncero, Isabel, Alvarez, Elvira, Acosta, Carlos, Sanz, Carmen, Barrio, Pedro, Hurtado-Carneiro, Veronica, Burks, Deborah, Blázquez, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613347/
https://ncbi.nlm.nih.gov/pubmed/23560040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058797
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