Regulation of ERα-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: Implications for breast cancer cell survival

Both estrogen, through the estrogen receptor (ER), and growth factors, through the phosphatidylinositol-3-kinase (PI3K)-AKT pathway, have been shown to independently promote cell survival. Here, we investigated the role of ER/PI3K-AKT crosstalk in the regulation of cell survival in MCF-7 breast carc...

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Main Authors: BRATTON, MELYSSA R., DUONG, BICH N., ELLIOTT, STEVEN, WELDON, CHRISTOPHER B., BECKMAN, BARBARA S., McLACHLAN, JOHN A., BUROW, MATTHEW E.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613138/
https://ncbi.nlm.nih.gov/pubmed/20664923
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