Synergistic Enhancement of Cellular Immune Responses by the Novel Toll Receptor 7/8 Agonist 3M 007 and Interferon-γ: Implications for Therapy of Cutaneous T-Cell Lymphoma

CTCL is responsive at all stages to immunotherapy. We determined whether a novel agonist for TLR 7/8 (3M007) combined with either IFN-γ or IL-15 enhanced patients' immune responses in vitro. Our data demonstrate synergism between IFN-γ and 007 in the activation of patients' NK cytolytic ac...

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Main Authors: Wysocka, Maria, Dawany, Noor, Benoit, Bernice, Kossenkov, Andrew V., Troxel, Andrea B., Gelfand, Joel M., Kelly-Sell, Michael, Showe, Louise C., Rook, Alain H.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612958/
https://ncbi.nlm.nih.gov/pubmed/21942329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2011.582202
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