ERK2-regulated TIMP1 Induces Hyperproliferation of K-Ras(G12D)-Transformed Pancreatic Ductal Cells

Pancreatic ductal adenocarcinoma (PDAC) commonly contains a mutation in K-Ras(G12D) and is characterized by a desmoplastic reaction composed of deregulated, proliferating cells embedded in an abnormal extracellular matrix (ECM). Our previous observations imply that inhibiting the mitogen-activated p...

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Bibliographic Details
Main Authors: Botta, Gregory P, Reichert, Maximilian, Reginato, Mauricio J, Heeg, Steffen, Rustgi, Anil K, Lelkes, Peter I
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612909/
https://ncbi.nlm.nih.gov/pubmed/23555182
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