Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

Ribosome stalling on eukaryotic mRNAs triggers cotranslational RNA and protein degradation through conserved mechanisms. For example, mRNAs lacking a stop codon are degraded by the exosome in association with its cofactor, the SKI complex, whereas the corresponding aberrant nascent polypeptides are...

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Detalhes bibliográficos
Main Authors: Defenouillère, Quentin, Yao, Yanhua, Mouaikel, John, Namane, Abdelkader, Galopier, Aurélie, Decourty, Laurence, Doyen, Antonia, Malabat, Christophe, Saveanu, Cosmin, Jacquier, Alain, Fromont-Racine, Micheline
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612664/
https://ncbi.nlm.nih.gov/pubmed/23479637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221724110
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