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PI3K inhibition potentiates Bcl-2-dependent apoptosis in renal carcinoma cells

Inhibitors of PI3-K/Akt are currently being assessed clinically in patients with advanced RCC. Identification of therapeutic strategies that might enhance the efficacy of PI3-K/Akt inhibitors is therefore of great interest. As PI3-K inhibition would be expected to have many pro-apoptotic effects, we...

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Autori principali: Zhu, Shudong, Cohen, Matthew B, Bjorge, Jeffrey D, Mier, James W, Cho, Daniel C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612143/
https://ncbi.nlm.nih.gov/pubmed/23387989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12019
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