Role of a Novel Functional Variant in the PPP2R1A Promoter on the Regulation of PP2A-Aalpha and the Risk of Hepatocellular Carcinoma

Previously, we identified the genetic variant −241 (−/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may...

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Detalhes bibliográficos
Main Authors: Chen, Hui-Feng, Mai, Jian-Rong, Wan, Jian-Xin, Gao, Yan-fang, Lin, Li-Na, Wang, Song-Zi, Chen, Yu-Xi, Zhang, Chen-Zi, Zhang, Yu-Jing, Xia, Bin, Liao, Kun, Lin, Yu-Chun, Lin, Zhong-Ning
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612049/
https://ncbi.nlm.nih.gov/pubmed/23555712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059574
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